[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].
Zhonghua Yi Xue Za Zhi
; 90(4): 236-40, 2010 Jan 26.
Article
en Zh
| MEDLINE
| ID: mdl-20356536
ABSTRACT
OBJECTIVE:
To investigate the association of Killer cell immunoglobin-like receptor (KIR) gene and KIRs'ligand (HLA-C) gene polymorphisms with type 1 diabetes (T1DM).METHODS:
Using polymerase chain reaction-sequence specific primer (PCR-SSP) to detect KIR and HLA-C genotype in 180 T1DM patients and 199 healthy controls from Hunan Han population.RESULTS:
(1) The frequencies of KIR 2DL1 (98.9% vs 92.0%, OR = 7.78, P = 0.002), 3DL1 (94.3% vs 86.4%, OR = 2.67, P = 0.009) and 2DS4 (83.9% vs 70.9%, OR = 2.14, P = 0.003) were significantly higher in T1DM patients than those in the controls. (2) There were no differences in the frequencies of HLA-C1 and HLA-C2 between the patients and the controls, but the frequency of HLAC1+/C2+ (3.9% vs 9.6%, OR = 0.38, P = 0.03) was significantly lower in the T1DM patients. (3) The combination KIR2DL1-/HLA-C2-(0.6% vs 6.0%, OR = 0.087, P = 0.003) and KIR 2DS1-/HLA-C2-(53.3% vs 64.8%, OR = 0.62, P = 0.023) was significantly lower in the T1DM patients.CONCLUSION:
The KIR gene polymorphism and KIR/HLA-C gene compatibility are associated with T1DM.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Antígenos HLA-C
/
Diabetes Mellitus Tipo 1
/
Receptores KIR2DL1
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2010
Tipo del documento:
Article
País de afiliación:
China