Smoothelin is a specific and robust marker for distinction of muscularis propria and muscularis mucosae in the gastrointestinal tract.
Histopathology
; 57(2): 244-9, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20716166
ABSTRACT
AIMS:
As tumour specimens and biopsy specimens become smaller, recognition of anatomical structures relevant for staging is increasingly challenging. So far no marker is known that reliably discriminates between muscularis propria (MP) and muscularis mucosae (MM) of the gastrointestinal tract. Recently, smoothelin expression has been shown to differ in MP and MM of the urinary bladder. We aimed to analyse the expression of smoothelin in the gastrointestinal tract in MP and MM in order to define a novel diagnostic tool to identify MM bundles. METHODS ANDRESULTS:
The expression of smoothelin was analysed immunohistochemically in comparison with alpha-smooth muscle actin (alpha-SMA) in specimens from colon, stomach and oesophagus (n = 107). In contrast to alpha-SMA, which equally stained MM and MP, absent or significantly weaker smoothelin expression was found in MM was found, which was particularly valid in colon and gastric specimens.CONCLUSIONS:
The combination of smoothelin and SMA represents a robust marker to discriminate MM from MP in the gastrointestinal tract.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas del Citoesqueleto
/
Tracto Gastrointestinal
/
Proteínas Musculares
Límite:
Humans
Idioma:
En
Revista:
Histopathology
Año:
2010
Tipo del documento:
Article
País de afiliación:
Suiza