Monoamine oxidase inhibition by moclobemide and 2-amino-ethyl carboxamide derivatives: mode of action and kinetic characteristics.
J Neural Transm Suppl
; 32: 165-70, 1990.
Article
en En
| MEDLINE
| ID: mdl-2089085
ABSTRACT
The selective, reversible inhibitors of monoamine oxidase (MAO) moclobemide and Ro 41-1049 (selective for MAO-A), as well as of Ro 16-6491 and Ro 19-6327 (selective for MAO-B) inhibited the enzyme with an initial competitive phase, followed by a time-dependent inhibition of MAO. Ro 41-1049, Ro 16-6491 and Ro 19-6327, being activated by MAO into reversible adducts, fit into the classification as mechanism-based inhibitors. Conversely, since no product formation was observed after incubation of tissue homogenates with moclobemide, this drug probably belongs to the class of the "slow-binding" MAO inhibitors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tiazoles
/
Benzamidas
/
Inhibidores de la Monoaminooxidasa
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Neural Transm Suppl
Año:
1990
Tipo del documento:
Article
País de afiliación:
Suiza