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Alveolar proteinosis with hypersensitivity pneumonitis: a new clinical phenotype.
Respirology ; 15(8): 1197-202, 2010 Nov.
Article en En | MEDLINE | ID: mdl-20920129
ABSTRACT
BACKGROUND AND

OBJECTIVE:

The aim of the present study was to report the features of five patients with concurrent histopathological features of pulmonary alveolar proteinosis (PAP) and hypersensitivity pneumonitis (HP) and their high-resolution CT (HRCT) appearances.

METHODS:

Patients with histopathological features of both HP and PAP on surgical lung biopsy referred for tertiary review were retrospectively identified. The pathology and HRCT images were semi-quantitatively scored to evaluate the relative contribution to HP and PAP.

RESULTS:

Five patients had histopathological features of HP and PAP but had varied HRCT appearances. All had imaging features of PAP to a varying degree with two patients also showing characteristics of HP but three patients had ill-defined thickened interlobular septa, not typical of either disease.

CONCLUSIONS:

We describe the coexistence of PAP and HP in five patients and discuss possible linkages between these two distinct pathologies.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteinosis Alveolar Pulmonar / Alveolitis Alérgica Extrínseca Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respirology Año: 2010 Tipo del documento: Article País de afiliación: Reino Unido

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteinosis Alveolar Pulmonar / Alveolitis Alérgica Extrínseca Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respirology Año: 2010 Tipo del documento: Article País de afiliación: Reino Unido