IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection.
Parasite Immunol
; 33(2): 132-6, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21226726
ABSTRACT
Cutaneous leishmaniasis (CL) is characterized by high production of pro-inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but do not develop disease. We evaluated whether the downregulation of inflammatory response in SC is mediated by IL-10 and IL-27 and whether IL-17 is associated with control of infection. Participants include SC individuals, patients with CL and healthy subjects. Cytokines protein and mRNA were detected by ELISA and real-time PCR. IFN-γ and TNF-α levels were higher in CL than in SC group. The IL-10 levels and mRNA for IL-10 were similar in both SC and CL. mRNA for IL-27 was increased in cells from SC after stimulation with L. braziliensis antigen. There was a tendency for increased levels of IL-17 in SC compared to CL. The weak type 1 immune response observed in SC L. braziliensis infection is not because of the regulatory effects of IL-10 and IL-27. The control of Leishmania infection may be mediated by innate immune response with participation of IL-17. The results from this pilot study warrant further larger studies to investigate the potential contributions of IL-17 and IL-27 to the control of L. braziliensis infection.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Leishmania braziliensis
/
Interleucinas
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Leishmaniasis Cutánea
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Interleucina-10
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Interleucina-17
/
Infecciones Asintomáticas
Límite:
Child
/
Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Parasite Immunol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Brasil