Potential bis-alkylating agents for cancer chemotherapy. Approaches to the synthesis of 2-sulfonyl-1,4-bis(methanesulfonoxy)butanes.
J Med Chem
; 21(11): 1168-71, 1978 Nov.
Article
en En
| MEDLINE
| ID: mdl-214556
ABSTRACT
Three general methods for the synthesis of derivatives of the bis-alkylating agent, myleran [1,4-bis(methane-sulfonoxy)butane (1)], are presented. These derivatives contain a lipophilic group attached to the 2 position of 1,4-bis(methanesulfonoxy)butane by means of a sulfonyl function. As examples of the scope of the methods, the synthesis of seven such derivatives (12a-g) is presented. All seven were inactive against L1210 and P388 leukemia in the mouse.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mesilatos
/
Alquilantes
Límite:
Animals
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
1978
Tipo del documento:
Article