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Epigenetic DNA methylation in the promoters of the Igf1 receptor and insulin receptor genes in db/db mice.
Nikoshkov, Andrej; Sunkari, Vivekananda; Savu, Octavian; Forsberg, Elisabete; Catrina, Sergiu-Bogdan; Brismar, Kerstin.
Afiliación
  • Nikoshkov A; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden. Andrej.Nikosjkov@ki.se
Epigenetics ; 6(4): 405-9, 2011 Apr.
Article en En | MEDLINE | ID: mdl-21474992
ABSTRACT
We have investigated promoter methylation of the Insr, Igf1 and Igf1r genes in skeletal and cardiac muscles of normal and diabetic db/db mice. No differences in Insr promoter methylation were found in the heart and skeletal muscles and no methylation was detected in the Igf1 promoter in skeletal muscle. In skeletal muscle, db/db males exhibited a 7.4-fold increase in Igf1r promoter methylation, which was accompanied by a 1.8-fold decrease in Igf1r mRNA levels, compared with controls. More than 50% of the detected methylation events were concentrated within an 18 bp sequence that includes one of the Sp1 binding sites. We conclude that the methylation level and pattern of the Igf1r promoter in skeletal muscle is related to gender and the diabetic state.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Regiones Promotoras Genéticas / Receptor IGF Tipo 1 / Metilación de ADN / Epigénesis Genética Límite: Animals Idioma: En Revista: Epigenetics Asunto de la revista: GENETICA Año: 2011 Tipo del documento: Article País de afiliación: Suecia
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Regiones Promotoras Genéticas / Receptor IGF Tipo 1 / Metilación de ADN / Epigénesis Genética Límite: Animals Idioma: En Revista: Epigenetics Asunto de la revista: GENETICA Año: 2011 Tipo del documento: Article País de afiliación: Suecia