Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes.
Antimicrob Agents Chemother
; 55(8): 3950-3, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21646489
ABSTRACT
The susceptibilities of vertilmicin and seven reference aminoglycosides to modifications by six recombinant aminoglycoside-modifying enzymes, AAC(6')-Ie, APH(2'')-Ia, AAC(6')-Ie-APH(2'')-Ia, ANT(2'')-Ia, AAC(6')-Ib, and AAC(6')-Ib-cr, were studied by coupled spectrophotometric assays in microtiter plates. In comparison to other aminoglycosides, the susceptibility of vertilmicin was 45.8- to 250.0-fold lower for AAC(6')-Ie acetylation, 39.2- to 116.7-fold lower for AAC(6')-Ie-APH(2'')-Ia acetylation, and 1.8- to 7.5-fold lower for ANT(2'')-Ia adenylation (except that shown by amikacin) while relatively comparable for AAC(6')-Ib acetylation, AAC(6')-Ib-cr acetylation, APH(2'')-Ia phosphorylation, and AAC(6')-Ie-APH(2'')-Ia phosphorylation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfotransferasas
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Acetiltransferasas
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Aminoglicósidos
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Antibacterianos
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Nucleotidiltransferasas
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2011
Tipo del documento:
Article
País de afiliación:
China