T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers.
AIDS Res Ther
; 8(1): 20, 2011 Jun 16.
Article
en En
| MEDLINE
| ID: mdl-21679427
ABSTRACT
BACKGROUND:
Elite controllers (EC) are a rare subset of HIV infected individuals who control viral load below 50 copies/ml of plasma without treatment.METHODS:
Thirty four EC were studied. The slope of CD4 count change was available for 25 of these subjects. We assessed immune activation by measuring the percent of CD38+HLA-DR+CD8+ T cells in the EC group and comparing it with that in 24 treatment-naïve HIV disease progressors and 13 HIV uninfected healthy controls.RESULTS:
Compared to HIV uninfected subjects, EC had higher percentages of CD38+HLA-DR+CD8+ T cells (p < 0.001) that was lower than that observed in progressors (p < 0.01). Fifteen of 25 EC had a slope of CD4 count change that was not significantly different from 0 while 3 had a positive and 7 a negative CD4 count slope. Immune activation did not distinguish EC subsets with stable/increasing versus declining CD4 counts.CONCLUSIONS:
Elevated immune activation in ECs is not associated with a faster rate of CD4 decline.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
AIDS Res Ther
Año:
2011
Tipo del documento:
Article
País de afiliación:
Canadá