[Efficacy of thalidomide for treatment of juvenile idiopathic arthritis].
Zhongguo Dang Dai Er Ke Za Zhi
; 13(8): 631-4, 2011 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-21849111
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of thalidomide in the treatment of juvenile idiopathic arthritis (JIA).METHODS:
Twelve children with JIA who did not respond to conventional treatment were administered with thalidomide (2 mg/kg daily). The symptoms, signs, and laboratory test results were compared before and after treatment. The thalidomide-related side effects were observed.RESULTS:
The average dosage of prednisone was reduced from 1.92 ± 0.16 mg/kgâ¢d to 0.49 ± 0.42 mg/kgâ¢d in the 12 patients 6 months after thalidomide treatment (P<0.01). Four patients did not need prednisone treatment any more. White blood cell count, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and serum ferritin (SF) significantly decreased after treatment in all of 12 patients (P<0.01). Hemoglobin level increased to normal in 8 patients after treatment (P<0.01). The number of affected joints decreased from 5 before treatment to zero to 2 after treatment in patients with polyarticular JIA (P<0.01). Signs of hip involvement and Schober's sign turned negative in enthesitis-related cases. No thalidomide-related side effects were observed.CONCLUSIONS:
Thalidomide is effective in the treatment of JIA in children who do not respond to conventional treatment.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Artritis Juvenil
/
Talidomida
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2011
Tipo del documento:
Article
País de afiliación:
China