Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.
Lab Invest
; 91(11): 1634-42, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-21876534
ABSTRACT
The cell cycle inhibitors p21(Waf1/Cip1) and p27(Kip1) are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of pituitary adenomas, pheochromocytomas and thyroid adenomas. The combined absence of p21 and p27 proteins delays the incidence of radiation-induced thymic lymphomas with a higher apoptotic rate, measured by active caspase-3 and cleaved PARP-1 immunoexpresion. These results provide experimental evidence for a cooperation of both cyclin-dependent kinase inhibitors in tumorigenesis in mice.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Transformación Celular Neoplásica
/
Inhibidor p21 de las Quinasas Dependientes de la Ciclina
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Inhibidor p27 de las Quinasas Dependientes de la Ciclina
Límite:
Animals
Idioma:
En
Revista:
Lab Invest
Año:
2011
Tipo del documento:
Article
País de afiliación:
España