Immune-related genes expression profile in orange-spotted grouper during exposure to Cryptocaryon irritans.
Parasite Immunol
; 33(12): 679-987, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21958410
ABSTRACT
Cryptocaryon irritans is one of the most important ectoparasites of marine fish. To identify the potential role of immune-related genes in antiparasitic immune responses in fish, we monitored the expression change of IL-8, COX-2, C-type lectin and transferrin in local and systemic immune organs of orange-spotted grouper post-C. irritans infection. IL-8 expression was up-regulated during the course of infection in the skin, while COX-2 and transferrin expression was up-regulated in the gill. COX-2 expression was significantly down-regulated in the spleen (0·7-5% of its control) and head kidney (0·5-4% of its control) post-primary infection. Transferrin expression was also down-regulated in the spleen and head kidney from 6 h to 5 days post-primary infection. However, C-type lectin expression was up-regulated in all tested organs post-infection, with the exception of day 7 in the spleen post-primary infection where the expression level was slightly down-regulated (44% of its control). These results suggest that these four immune-related genes play an important role in grouper anti-C. irritans infection and that local immune organs as the active organs contribute more than systemic immune organs to this course.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Lubina
/
Infecciones por Cilióforos
/
Cilióforos
/
Enfermedades de los Peces
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Parasite Immunol
Año:
2011
Tipo del documento:
Article
País de afiliación:
China