Acute New World cutaneous leishmaniasis presenting as tuberculoid granulomatous dermatitis.
J Cutan Pathol
; 39(3): 361-5, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22236114
ABSTRACT
Acute primary cutaneous leishmaniasis typically presents microscopically with a lymphohistiocytic infiltrate containing admixed plasma cells, parasitized macrophages and abundant organisms. Tuberculoid granulomatous changes may occur in the later phases of primary infection. A 23-year-old male presented 1 month after visiting Peru with classic clinical findings of acute primary cutaneous leishmaniasis, while histopathology showed a tuberculoid granulomatous process that lacked any organisms in hematoxylin-eosin and fungal stains. Polymerase chain reaction (PCR) analysis and tissue cultures confirmed the diagnosis of cutaneous leishmaniasis with Leishmania (Viannia) panamensis infection. A pauci-organism tuberculoid granulomatous process may uncommonly be the presenting histopathology in the acute infectious phase of cutaneous leishmaniasis. Clinicians and dermatopathologists should be aware of this atypical presentation, which may cause diagnostic confusion and delay proper treatment. PCR testing should be employed in cases with high clinical suspicion when histopathology is not definitive.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis Cutánea
/
Leishmaniasis Mucocutánea
/
Reacción en Cadena de la Polimerasa
/
Leishmania guyanensis
/
Dermatitis
/
Granuloma
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Peru
Idioma:
En
Revista:
J Cutan Pathol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos