Isolation of zidovudine resistant Escherichia coli from AIDS patients.
FEMS Microbiol Lett
; 58(2): 141-3, 1990 Jul.
Article
en En
| MEDLINE
| ID: mdl-2227349
ABSTRACT
Zidovudine-resistant Escherichia coli were isolated from faecal samples from 6 out of 11 AIDS patients receiving zidovudine. Resistance appeared to be due to the loss of thymidine kinase activity which is required for the phosphorylation of zidovudine to its active form. No zidovudine resistant enterobacteria were isolated from 30 control faecal samples. Hence, clinically, there appeared to be a high correlation between the development of zidovudine-resistance in E. coli and exposure to zidovudine (chi 2 11.77, P less than 0.001). However the development of zidovudine resistance does not appear to be associated with cross-resistance to other antimicrobial agents as the zidovudine-resistant E. coli did not display a high degree of resistance to other antibacterials.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Farmacorresistencia Microbiana
/
Zidovudina
/
Síndrome de Inmunodeficiencia Adquirida
/
Escherichia coli
Límite:
Humans
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
1990
Tipo del documento:
Article
País de afiliación:
Reino Unido