Effect of topical clay application on the synthesis of collagen in skin: an experimental study.
Clin Exp Dermatol
; 37(2): 164-8, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22340693
ABSTRACT
BACKGROUND:
Clay is often used in cosmetic treatments, although little is known about its action.AIM:
To evaluate the effect of topical clay application on the histoarchitecture of collagen fibres in rat skin.METHODS:
Animals received a daily application of clay and retinoic acid (RA) 0.025% to the dorsal skin over 7 and 14 days, under vaporization at 37 °C for 40 min. Control skin was not vaporized. Samples from each region were excised, and stained with picrosirius red for collagen evaluation.RESULTS:
Seven days after clay treatment, an increase in the number of collagen fibres was observed in treated skin compared with control skin (51.74 ± 1.28 vs. 43.39 ± 1.79%, respectively, P < 0.01), whereas RA did not alter the collagen level (45.66 ± 1.10%). Clay application over 14 days did not induce a further increase in skin collagen, whereas treatment with RA did (58.07 ± 1.59%; P = 0.001 vs. control).CONCLUSION:
Clay application promotes an increase in the number of collagen fibres, which may account for its beneficial effects.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Colágeno
/
Cosméticos
/
Silicatos de Aluminio
Límite:
Animals
Idioma:
En
Revista:
Clin Exp Dermatol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Brasil