Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin.
Eur J Pharm Sci
; 47(3): 556-63, 2012 Oct 09.
Article
en En
| MEDLINE
| ID: mdl-22884627
ABSTRACT
A series of polymers were synthesized by cross-linking carboxyl poly(glycerol methacrylate) (PGOHMA) using hexamethylene diisocyanate (HDI). The structures and molecular weight were characterized by ¹H NMR and gel permeation chromatography (GPC). Nanoparticles were then fabricated for encapsulation of doxorubicin hydrochloride (DOX). The encapsulation and release were affected by the chemical structure and degree of cross-linking of the polymers. The polymers were quite effective in the encapsulation of DOX, and exhibited pH-dependent drug release. Specifically, the stability of nanoparticles in neutral pH was significant enhanced and the release rate was enhanced at acidic pH after cross-linking, which could be potential useful as a controlled drug release carrier, especially for anti-cancer drug.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polímeros
/
Portadores de Fármacos
/
Doxorrubicina
/
Preparaciones de Acción Retardada
/
Metacrilatos
/
Antibióticos Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
Eur J Pharm Sci
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
China