Evaluation of the antiseptic efficacy and local tolerability of a polihexanide-based antiseptic on resident skin flora.
Adv Skin Wound Care
; 25(9): 404-8, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22914036
ABSTRACT
OBJECTIVE:
The primary objective of this study was to compare the antimicrobial efficacy of polihexanide 0.02% and 0.04% with chlorhexidine 0.05% after 30 minutes of topical treatment on healthy intact skin.DESIGN:
This study was performed as a double-blind, randomized, comparator-controlled, 3-arm, crossover study.SETTING:
A phase I dermatological study unit.PARTICIPANTS:
Twenty healthy volunteers with intact skin.INTERVENTIONS:
Test areas of 5 cm on the subjects' arms were treated with the investigational products using a polyurethane swab. Skin swabs were taken before and after treatment for quantitative microbial evaluation. MAIN OUTCOMEMEASURES:
The main outcome measure was the log reduction factor of colony-forming units on the skin after 30 minutes of treatment. MAINRESULTS:
No statistically significant difference was seen between both of the polihexanide test products (mean lgRF polihexanide 0.02%, 1.2251 [SD, 0.9399]; mean lgRF polihexanide 0.04%, 1.8991 [SD, 0.88]) and the comparator, chlorhexidine 0.05% (P > .1).CONCLUSION:
The results of this study indicate that polihexanide is a suitable alternative to chlorhexidine for skin and wound antisepsis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Biguanidas
/
Clorhexidina
/
Antiinfecciosos Locales
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Adv Skin Wound Care
Asunto de la revista:
ENFERMAGEM
Año:
2012
Tipo del documento:
Article
País de afiliación:
Suiza