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Soluble CD163 is associated with body mass index and blood pressure in hypertensive obese Saudi patients.
Al-Daghri, Nasser M; Al-Attas, Omar S; Bindahman, Lotfi S; Alokail, Majed S; Alkharfy, Khalid M; Draz, Hossam M; Yakout, Sobhy; McTernan, Philip G; Sabico, Shaun; Chrousos, George P.
Afiliación
  • Al-Daghri NM; Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. aldaghri2011@gmail.com
Eur J Clin Invest ; 42(11): 1221-6, 2012 Nov.
Article en En | MEDLINE | ID: mdl-22946776
ABSTRACT

BACKGROUND:

The hallmark of vascular inflammation is the recruitment of circulating leucocytes, primarily monocytes, macrophages and T lymphocytes, into the vascular wall; however, the link between monocyte/macrophage activation and hypertension has not been established as yet. In this study, we determined how sCD163, a monocyte/macrophage soluble scavenger receptor and immunomodulator, relates to arterial blood pressure (BP) in hypertensive Saudi individuals. MATERIALS AND

METHODS:

A total of 90 (30 non-hypertensive obese, 30 hypertensive obese and 30 lean normotensive controls) adult Saudi subjects, aged 40-60 years, participated in this cross-sectional study. Serum fasting blood glucose, triglycerides, total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), leptin, adiponectin, resistin, insulin, tumour necrosis factor-alpha (TNF-α), PAI-1, angiotensin II, high-sensitivity C-reactive protein (hsCRP) and sCD163 were measured in all subjects studied.

RESULTS:

sCD163 concentrations were significantly increased in obese hypertensive patients compared to controls (P=0.016). Positive correlations between sCD163 and body mass index (BMI) (r=0.27, P=0.01), systolic BP (r=0.25, P=0.01), diastolic BP (r=0.33, P=0.001), LDL-C (r=0.21, P=0.04), TNF-α (r=0.23, P=0.02) and hsCRP (r=0.33, P=0.008) were observed. Positive correlations between sCD163 and diastolic BP (r=0.23, P=0.04) and LDL-C (r=0.22, P=0.03) remained significant after controlling for BMI.

CONCLUSIONS:

Taken together, these data demonstrate that the monocyte/macrophage activation-related sCD163 is positively associated with BMI and increased arterial BP with the elevation in diastolic BP being independent of the BMI.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Presión Sanguínea / Antígenos de Diferenciación Mielomonocítica / Antígenos CD / Índice de Masa Corporal / Receptores de Superficie Celular / Hipertensión / Obesidad Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Eur J Clin Invest Año: 2012 Tipo del documento: Article País de afiliación: Arabia Saudita

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Presión Sanguínea / Antígenos de Diferenciación Mielomonocítica / Antígenos CD / Índice de Masa Corporal / Receptores de Superficie Celular / Hipertensión / Obesidad Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Eur J Clin Invest Año: 2012 Tipo del documento: Article País de afiliación: Arabia Saudita