Changes in activity of proline-specific peptidases in rat model for dementia of Alzheimer's type.
Bull Exp Biol Med
; 153(5): 674-6, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-23113255
ABSTRACT
We studied the role of proline-specific peptidases in the pathogenesis of Alzheimer's disease. Testing of conditioned passive avoidance 24 h after learning showed that chronic administration of scopolamine to rats 4-fold reduced the latency of entry into the dark chamber in comparison with controls (intact animals). Activity of prolyl endopeptidase was significantly higher than in the controls in both the cortex and hippocampus. Changes in dipeptidyl peptidase IV activity were observed only in the cortex. Injection of AF-64A toxin into Meynert nucleus basalis reduced the latency of entry into the dark compartment by 75% in comparison with that in sham-operated and intact controls. Prolyl endopeptidase activity was reduced in the frontal cortex and hippocampus, but not in hypothalamus. Changes in dipeptidyl peptidase IV activity were detected only in the frontal cortex.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Reacción de Prevención
/
Serina Endopeptidasas
/
Dipeptidil Peptidasa 4
/
Enfermedad de Alzheimer
/
Amnesia
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
Rusia