[Similarity of cycloprolylglycine to piracetam in antihypoxic and neuroprotective effects].
Eksp Klin Farmakol
; 75(9): 3-6, 2012.
Article
en Ru
| MEDLINE
| ID: mdl-23156079
ABSTRACT
The antihypoxic activity of the endogenous cyclic dipeptide cycloprolylglycine (CPG) has been studied on a model of normobaric hypoxia with hypercapnia and its neuroprotective activity has been studied on a model of human neuroblastoma SH-SY5Y cell damage by 6-hydroxydopamine. It is established that CPG exhibits the antihypoxic activity at doses of 0.5 and 1.0 mg/kg (i.p.) on outbred and BALB/c mice, but not on C57B1/6 mice. The neuroprotective activity of CPG was detected in 10(-5) - 10(-8) M concentration range only when the treatment was carried out 24h before toxin introduction. The obtained data confirm the hypothesis that piracetam is a mimetic of the endogenous CPG neuropeptide.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos Cíclicos
/
Piracetam
/
Fármacos Neuroprotectores
/
Hipercapnia
/
Hipoxia
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
2012
Tipo del documento:
Article