HLA-DRB and HLA-DQA/HLA-DQB allele and haplotype frequencies in Iranian patients with aggressive periodontitis.
J Periodontal Res
; 48(4): 533-9, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23317308
ABSTRACT
BACKGROUND AND OBJECTIVE:
Genetic backgrounds play a key role in susceptibility to and protection against a spectrum of periodontal diseases. Like other infectious diseases, the human leukocyte antigen (HLA) have been found to be associated with periodontitis. This study aimed to investigate differences in allele and haplotype frequencies of HLA class II antigens in a sample of Iranian patients with aggressive periodontitis compared with a healthy control group. MATERIAL ANDMETHODS:
Fifty unrelated patients with aggressive periodontitis and 130 healthy volunteers were enrolled in this study. HLA genotyping for HLA-DRB, HLA-DQA1 and HLA-DQB1 was performed using the PCR with sequence-specific primers. Allele and haplotype frequencies were compared across groups.RESULTS:
The frequencies of HLA-DQA1*0301, HLA-DQB1*0302 and HLA-DQB1*0305 alleles, as well as that of the HLA-DRB1*0401 allele, were significantly higher in patients with aggressive periodontitis compared with control subjects (p = 0.01, p = 0.04, p = 0.05 and p = 0.04, respectively). In contrast, the frequency of the HLA-DQB1*0603 allele was significantly lower in patients with aggressive periodontitis compared with control subjects (p = 0.006; odds ratio = 0.20). With regard to haplotype association, a significantly higher frequency of two haplotypes - HLA-DRB1*0401/HLA-DQA1*0301/HLA-DQB1*0302 and HLA-DRB1*1601/HLA-DQA1*0103/HLA-DQB1*0501 - was observed in patients with aggressive periodontitis compared with healthy controls (p = 0.01, odds ratio = 2.56 and p = 0.05, odds ratio = 5.38, respectively).CONCLUSION:
These results provide additional evidence that class II HLA polymorphisms, particularly in the DQ locus, are associated with protection against and susceptibility to aggressive periodontitis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Periodontitis Agresiva
/
Haplotipos
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Cadenas alfa de HLA-DQ
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Cadenas beta de HLA-DQ
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Cadenas beta de HLA-DR
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Frecuencia de los Genes
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Periodontal Res
Año:
2013
Tipo del documento:
Article
País de afiliación:
Irán