A new perspective on the pathobiology of keratoconus: interplay of stromal wound healing and reactive species-associated processes.
Clin Exp Optom
; 96(2): 188-96, 2013 Mar.
Article
en En
| MEDLINE
| ID: mdl-23336806
ABSTRACT
Severe loss of vision manifests from the corneal protrusion, thinning and distortion that characterises keratoconus, which in its most severe form is still treated primarily by lamellar or penetrating keratoplasty. Unfortunately, alternative therapeutic options targeting the underlying pathobiology remain limited, attributable to an incomplete understanding of the biological mechanisms instigating stromal deterioration and other disease processes. We postulate that underlying abnormalities in stromal repair and reactive species-linked activities and the interaction between these phenomena are implicated in the development of keratoconus. This revised interpretation of the pathophysiology may, with further investigation, advance our knowledge and the clinical management of this prevalent ectatic disorder.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
/
Queratocono
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Optom
Asunto de la revista:
OPTOMETRIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda