Detection of hypermethylated spastic paraplegia-20 in stool samples of patients with colorectal cancer.
Int J Med Sci
; 10(3): 230-4, 2013.
Article
en En
| MEDLINE
| ID: mdl-23372428
ABSTRACT
BACKGROUND:
Analysis of aberrant hypermethylation in stool DNA might provide a novel strategy for noninvasive detection of colorectal cancer.AIMS:
To explore the feasibility of detecting hypermethylation in Spastic paraplegia-20 promoter as a stool-based DNA marker for detection of colorectal cancer.METHODS:
We collected 96 tissue and stool samples from patients with colorectal cancer and 30 stool samples healthy individuals.RESULTS:
Hypermethylated Spastic paraplegia-20 occurs in 85.4% (82/96) of patients with colorectal cancer in the tissue samples. In the stool samples, the results indicate 80.2% (77/96) sensitivity and 100% (30/30) specificity of the test for detecting colorectal cancer by using the stool samples as a noninvasive method.CONCLUSIONS:
The study reveals that hypermethylation in Spastic paraplegia-20 promoter is a highly specific and sensitive biomarker for screening colorectal cancer in stool samples as a noninvasive method.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Paraplejía
/
ADN
/
Neoplasias Colorrectales
/
Proteínas
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Med Sci
Asunto de la revista:
MEDICINA
Año:
2013
Tipo del documento:
Article
País de afiliación:
China