[Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia].
Fa Yi Xue Za Zhi
; 28(6): 418-21, 2012 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-23484320
ABSTRACT
OBJECTIVE:
To investigate the population genetic data of 3 SNP loci (rs25533, rs34388196 and rs1042173) of 5-hydroxytryptamine transporter (5-HTT) gene and the association with paranoid schizophrenia.METHODS:
Three SNP loci of 5-HTT gene were examined in 132 paranoid schizophrenia patients and 150 unrelated healthy individuals of Northern Chinese Han population by PCR-RFLP technique. The Hardy-Weinberg equilibrium test was performed using the chi-square test and the data of haplotype frequency and population genetics parameters were statistically analyzed.RESULTS:
Among these three SNP loci, four haplotypes were obtained. There were no statistically significant differences between the patient group and the control group (P > 0.05). The DP values of the 3 SNP loci were 0.276, 0.502 and 0.502. The PIC of them were 0.151, 0.281 and 0.281. The PE of them were 0.014, 0.072 and 0.072.CONCLUSION:
The three SNP loci and four haplotypes of 5-HTT gene have no association with paranoid schizophrenia, while the polymorphism still have high potential application in forensic practice.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia Paranoide
/
Reacción en Cadena de la Polimerasa
/
Polimorfismo de Nucleótido Simple
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Fa Yi Xue Za Zhi
Asunto de la revista:
JURISPRUDENCIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
China