Is verbal episodic memory in elderly with amyloid deposits preserved through altered neuronal function?
Cereb Cortex
; 24(8): 2210-8, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-23537530
ABSTRACT
A potential mechanism that enables intellectual preservation in cognitively normal elderly that harbor beta-amyloid (Aß) pathology is heightened cerebral glucose metabolism. To investigate cross-sectional inter-relationships between Aß, glucose metabolism, and cognition, 81 subjects (mean age 75 ± 7 years) underwent [(11)C]Pittsburgh Compound-B and [(18)F]fluorodeoxyglucose positron emission tomography scans and neuropsychological testing. They were divided into low-Aß (n = 53), intermediate-Aß (n = 13) and high-Aß (n = 15) groups as defined by their global cortical [(11)C]PIB retention. Glucose metabolism was assessed using a MetaROI mask that covers metabolically critical regions in Alzheimer's disease (AD) (i.e., posterior cingulate and bilateral angular and inferior temporal gyri). Previously validated factor scores for verbal and visual episodic memory, semantic memory, working memory, and executive functioning were used to evaluate cognitive performances. Greater Aß deposition in the precuneus was associated with higher metabolic activity (at trend level) and lower visual episodic memory scores. Glucose metabolism did not correlate with cognition across all subjects. However, heightened metabolic activity was associated with better verbal episodic memory performance in subjects with elevated amyloid levels. This preliminary study suggests that neural compensation, as a manifestation of brain reserve, enables elderly supposedly on the path to AD, at least temporarily, to preserve cognitive function.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Percepción del Habla
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Encéfalo
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Placa Amiloide
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Memoria Episódica
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Cereb Cortex
Asunto de la revista:
CEREBRO
Año:
2014
Tipo del documento:
Article
País de afiliación:
Países Bajos