Responses of regional cerebral blood flow following focal electrical stimulation of the nucleus basalis of Meynert and the medial septum using the [14C]iodoantipyrine method in rats.
Neurosci Lett
; 112(2-3): 263-8, 1990 May 04.
Article
en En
| MEDLINE
| ID: mdl-2359526
ABSTRACT
The effects of focal electrical stimulation of the nucleus basalis of Meynert (NBM) and the medial septum (MS) on regional cerebral blood flow (rCBF) of the 14 brain regions were examined in halothane-anesthetized rats using the [14C]iodoantipyrine ([14C]IAP) method. The stimulation of the unilateral NBM (with parameters of 200 microA, 0.5 ms, 50 Hz for 60 s) produced significant increases in frontal, parietal and occipital cortical blood flows in the hemisphere ipsilateral to the stimulated NBM; no rCBFs in all other brain regions examined were influenced by the stimulation. The stimulation of the MS produced significant increases in bilateral hippocampal rCBFs, but rCBFs in other brain regions were not influenced by the stimulation. In summary, the response of increase in rCBF following focal electrical stimulation of the NBM or MS is restricted to regions that receive cholinergic nerve projections from the NBM or MS.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Núcleos Septales
/
Encéfalo
/
Circulación Cerebrovascular
/
Antipirina
/
Lóbulo Frontal
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón