Inference of dynamic networks using time-course data.

ABSTRACT

Cells execute their functions through dynamic operations of biological networks. Dynamic networks delineate the operation of biological networks in terms of temporal changes of abundances or activities of nodes (proteins and RNAs), as well as formation of new edges and disappearance of existing edges over time. Global genomic and proteomic technologies can be used to decode dynamic networks. However, using these experimental methods, it is still challenging to identify temporal transition of nodes and edges. Thus, several computational methods for estimating dynamic topological and functional characteristics of networks have been introduced. In this review, we summarize concepts and applications of these computational methods for inferring dynamic networks and further summarize methods for estimating spatial transition of biological networks.