Beneficial effects of ß-conglycinin on renal function and nephrin expression in early streptozotocin-induced diabetic nephropathy rats.
Br J Nutr
; 111(1): 78-85, 2014 Jan 14.
Article
en En
| MEDLINE
| ID: mdl-23803175
ABSTRACT
The objective of the present study was to investigate the effects of ß-conglycinin and soya isoflavones on diabetic nephropathy (DN). DN was induced by an intravenous injection of streptozotocin (25 mg/kg) in spontaneously hypertensive rats. DN rats were divided into a non-diabetic group (C, control group) and three DN groups (D, DN with control diet; B, DN+control diet with one-eighth of casein replaced by ß-conglycinin as the protein source; and I, DN+control diet with 0·01 % soya isoflavones). After a 4-week experimental period, we found that fasting blood sugar and plasma and kidney advanced glycation end product levels and 24 h urinary protein excretion of the B group were significantly lower than those of the D group and insulin sensitivity and nephrin expression of the B group were significantly higher than those of the D group. In addition, systolic blood pressure, angiotensin-converting enzyme activity, angiotensin II level and plasma TAG level of the B group were significantly lower than those of the D group, whereas only the levels of plasma TAG and thiobarbituric acid-reactive substances of the I group were lower than those of the D group. In conclusion, ß-conglycinin may be beneficial for retarding DN progression and this effect cannot be completely explained by its isoflavone content.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Glycine max
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Proteínas en la Dieta
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Proteínas de Soja
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Nefropatías Diabéticas
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Antígenos de Plantas
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Proteínas de Almacenamiento de Semillas
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Globulinas
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Isoflavonas
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Riñón
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Proteínas de la Membrana
Idioma:
En
Revista:
Br J Nutr
Año:
2014
Tipo del documento:
Article