Reversion and conversion of interferon-γ release assay results in HIV-1-infected individuals.
J Infect Dis
; 209(5): 729-33, 2014 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-23911707
ABSTRACT
In this prospective study, human immunodeficiency virus type 1 (HIV-1)-infected subjects underwent QuantiFERON-TB Gold In-Tube interferon-γ release assay (IGRA) testing at baseline and after 24 months in a low tuberculosis incidence country. Concordant baseline and follow-up results were observed in 86% (n = 686 of 794) of subjects. IGRA conversions occurred in 9% (n = 63 of 718), whereas IGRA reversions were seen in 33% (n = 25 of 76) of individuals. Of the 10 active tuberculosis cases during follow-up, 5 had concordant positive IGRA results and 2 were IGRA converters. Although the clinical significance of IGRA conversions and reversions remains to be established, repeated IGRA testing seems to be of value in HIV-1-infected individuals.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tuberculosis
/
Infecciones por VIH
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Interferón gamma
Tipo de estudio:
Observational_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Infect Dis
Año:
2014
Tipo del documento:
Article