Modelling of tumour growth and cytotoxic effect of docetaxel in xenografts.
Comput Methods Programs Biomed
; 114(3): e3-13, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-23948442
ABSTRACT
One of the major sources of information on physiological and pathophysiological effects in pre-clinical oncology studies is the xenografted tumour animal model. However, measurement of tumour volume over time potentially masks a range of biological changes that the xenograft is undergoing. In this paper a mechanistic model of tumour growth in xenografts is presented that can be used to investigate the mode of drug action with respect to phenotypic changes. The model encapsulates key histological biomarkers and spatial constraints. The unknown model parameters are first shown to be uniquely identifiable from the proposed experimental studies, and then estimated from the resulting data using the anti-cancer agent docetaxel.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ensayos de Selección de Medicamentos Antitumorales
/
Taxoides
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Comput Methods Programs Biomed
Asunto de la revista:
INFORMATICA MEDICA
Año:
2014
Tipo del documento:
Article