Fucoidan induces G1 phase arrest and apoptosis through caspases-dependent pathway and ROS induction in human breast cancer MCF-7 cells.

Banafa, Amal M; Roshan, Sadia; Liu, Yun-Yi; Chen, Hui-Jie; Chen, Ming-Jie; Yang, Guang-Xiao; He, Guang-Yuan

Banafa, Amal M; Roshan, Sadia; Liu, Yun-Yi; Chen, Hui-Jie; Chen, Ming-Jie; Yang, Guang-Xiao; He, Guang-Yuan.

Afiliación

Banafa AM; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Roshan S; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Liu YY; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Chen HJ; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Chen MJ; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Yang GX; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. ygx@mail.hust.edu.cn.
He GY; The Genetic Engineering International Cooperation Base of Ministry of Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China. hegy@hust.edu.cn.

J Huazhong Univ Sci Technolog Med Sci ; 33(5): 717-724, 2013 Oct.

Article en En | MEDLINE | ID: mdl-24142726

Asunto(s)

Apoptosis/efectos de los fármacos; Caspasas/metabolismo; Puntos de Control de la Fase G1 del Ciclo Celular/efectos de los fármacos; Polisacáridos/farmacología; Especies Reactivas de Oxígeno/metabolismo; Antineoplásicos/química; Antineoplásicos/farmacología; Apoptosis/genética; Western Blotting; Neoplasias de la Mama/genética; Neoplasias de la Mama/metabolismo; Neoplasias de la Mama/patología; Caspasa 8/genética; Caspasa 8/metabolismo; Caspasas/genética; Proliferación Celular/efectos de los fármacos; Tamaño de la Célula/efectos de los fármacos; Ciclina D1/genética; Ciclina D1/metabolismo; Quinasa 4 Dependiente de la Ciclina/genética; Quinasa 4 Dependiente de la Ciclina/metabolismo; Citocromos c/genética; Citocromos c/metabolismo; Relación Dosis-Respuesta a Droga; Fucus/química; Puntos de Control de la Fase G1 del Ciclo Celular/genética; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Células MCF-7; Microscopía Fluorescente; Estructura Molecular; Polisacáridos/química; Proteínas Proto-Oncogénicas c-bcl-2/genética; Proteínas Proto-Oncogénicas c-bcl-2/metabolismo; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa; Transducción de Señal/efectos de los fármacos; Proteína X Asociada a bcl-2/genética; Proteína X Asociada a bcl-2/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Polisacáridos / Especies Reactivas de Oxígeno / Apoptosis / Caspasas / Puntos de Control de la Fase G1 del Ciclo Celular Idioma: En Revista: J Huazhong Univ Sci Technolog Med Sci Asunto de la revista: MEDICINA Año: 2013 Tipo del documento: Article País de afiliación: China

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