In vivo antibacterial activity of MRX-I, a new oxazolidinone.
Antimicrob Agents Chemother
; 58(4): 2418-21, 2014.
Article
en En
| MEDLINE
| ID: mdl-24395231
ABSTRACT
MRX-I is a potent oxazolidinone antibiotic against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). In this study, the in vivo efficacy of orally administered MRX-I was evaluated using linezolid as a comparator. MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Penicilinas
/
Oxazolidinonas
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2014
Tipo del documento:
Article