Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia.
Biol Blood Marrow Transplant
; 20(5): 739-42, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24468638
ABSTRACT
Although hypereosinophilia (HE) associated with chronic graft-versus-host disease (GVHD) has long been recognized, biological data on this phenomenon are scarce. Here we compare patients with chronic GVHD with HE together with a clonal T cell expansion and control patients with acute or chronic GVHD but without HE. These clonal expansions share a CD8(+) TC1 phenotype rather than a CD4(+) Th2 profile. In contrast to the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, these allogeneic CD8(+) clones do not recognize the epitopes of herpesviruses. Furthermore, these TC1 clones do not produce IL-17 as described in the DRESS syndrome.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Neoplasias Hematológicas
/
Trasplante de Células Madre de Sangre Periférica
/
Eosinofilia
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Blood Marrow Transplant
Asunto de la revista:
HEMATOLOGIA
/
TRANSPLANTE
Año:
2014
Tipo del documento:
Article
País de afiliación:
Francia