Analgesic action of methylphenidate on parkinsonian sensory symptoms. Mechanisms and pathophysiological implications.
Arch Neurol
; 45(9): 973-6, 1988 Sep.
Article
en En
| MEDLINE
| ID: mdl-2458094
ABSTRACT
Intravenous administration of methylphenidate hydrochloride, a central stimulant, was unexpectedly found to exert a potent analgesic effect on primary sensory symptoms in a group of patients with Parkinson's disease. This effect, which has now been studied in a short-term, double-blind, placebo-controlled experiment, subsequently disappeared if patients were pretreated with a beta-blocker or with a serotonin antagonist. Cerebrospinal fluid monoamine metabolites were determined in some of these patients, and the 5-hydroxyindoleacetic acid level was found to be significantly lower than in parkinsonian patients without pain and in normal volunteers. Given the mechanism of action of methylphenidate on the central nervous system, the adrenergic and serotoninergic mediation of its analgesic effect, and the demonstration of impaired central serotonin metabolism in the patient group, it is concluded that not only central dopaminergic deficiency but also altered noradrenergic and serotoninergic transmission in the spinal cord are quite likely to play a role in the pathophysiology of pain in Parkinson's disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cuidados Paliativos
/
Enfermedad de Parkinson
/
Sensación
/
Analgésicos
/
Metilfenidato
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
Límite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Neurol
Año:
1988
Tipo del documento:
Article
País de afiliación:
Italia