Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand.
Virol J
; 11: 48, 2014 Mar 12.
Article
en En
| MEDLINE
| ID: mdl-24620925
ABSTRACT
BACKGROUND:
The plaque reduction neutralization test (PRNT) is currently the best and most widely accepted approach to measuring virus-neutralizing and protective antibodies to dengue virus, and in assessing the immunogenicity of a dengue vaccine. However, the correlation between presence of dengue-neutralizing antibody and protection from infection is not absolute.FINDINGS:
In a cohort study in Ratchaburi Province, Thailand, 48 subjects with serologically confirmed symptomatic dengue infection were tested for pre-existing dengue neutralizing antibody using PRNT. Nine subjects had quite high pre-existing PRNT50 titers (titer >90) to subsequent infecting dengue serotypes, but still had symptomatic infections.CONCLUSION:
This report provides evidence that PRNT may not be a good test for predicting protection against subsequent dengue infection.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ensayo de Placa Viral
/
Pruebas de Neutralización
/
Dengue
/
Virus del Dengue
/
Anticuerpos Neutralizantes
/
Anticuerpos Antivirales
Tipo de estudio:
Etiology_studies
/
Evaluation_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Virol J
Asunto de la revista:
VIROLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Tailandia