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Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.
Beilhartz, Greg L; Ngure, Marianne; Johns, Brian A; DeAnda, Felix; Gerondelis, Peter; Götte, Matthias.
Afiliación
  • Beilhartz GL; From the Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada.
  • Ngure M; From the Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada.
  • Johns BA; the Departments of Medicinal Chemistry.
  • DeAnda F; Computational Chemistry, and.
  • Gerondelis P; Virology, Infectious Diseases Therapeutic Area Unit, GlaxoSmithKline, Research Triangle Park, North Carolina 27709.
  • Götte M; From the Department of Microbiology and Immunology, McGill University, Montreal, Quebec H3A 2B4, Canada, the Department of Biochemistry, McGill University, Montreal, Quebec H3G1Y6, Canada, and the Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec H3A 1A3,
J Biol Chem ; 289(23): 16270-7, 2014 Jun 06.
Article en En | MEDLINE | ID: mdl-24719329

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinonas / Ribonucleasa H / Inhibidores de la Transcriptasa Inversa / Transcriptasa Inversa del VIH Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Piridinas / Pirimidinonas / Ribonucleasa H / Inhibidores de la Transcriptasa Inversa / Transcriptasa Inversa del VIH Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article País de afiliación: Canadá