Simulation of Finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland.

Wang, Sophie R; Agarwala, Vineeta; Flannick, Jason; Chiang, Charleston W K; Altshuler, David; Hirschhorn, Joel N

Wang, Sophie R; Agarwala, Vineeta; Flannick, Jason; Chiang, Charleston W K; Altshuler, David; Hirschhorn, Joel N.

Afiliación

Wang SR; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Agarwala V; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Program in Biophysics, Graduate School of Arts and Sciences, Harvard Univ
Flannick J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Chiang CW; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Altshuler D; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Biology, Massachusett
Hirschhorn JN; Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: joelh@broadinstitute.org.

Am J Hum Genet ; 94(5): 710-20, 2014 May 01.

Article en En | MEDLINE | ID: mdl-24768551

Asunto(s)

Simulación por Computador; Efecto Fundador; Modelos Genéticos; Población/genética; Población Blanca/genética; Diabetes Mellitus Tipo 2/genética; Exoma/genética; Finlandia; Humanos; Herencia Multifactorial/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Población / Simulación por Computador / Efecto Fundador / Población Blanca / Modelos Genéticos Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Europa Idioma: En Revista: Am J Hum Genet Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google