Integrin signalling and traffic during axon growth and regeneration.
Curr Opin Neurobiol
; 27: 179-85, 2014 Aug.
Article
en En
| MEDLINE
| ID: mdl-24793179
ABSTRACT
Adult corticospinal tract axons do not regenerate because they have low intrinsic growth ability, and are exposed to inhibitory molecules after injury. PNS axons have a better regenerative capacity, mediated in part by integrins (extracellular matrix receptors). These are subject to complex regulation by signalling and trafficking. Recent studies have found that integrin mediated axon growth relies on signalling via focal adhesion molecules, and that integrins are inactivated by inhibitory molecules in the CNS. Forced activation of integrins can overcome inhibition and increase axon regeneration, however integrins are not transported into some CNS axons. Studies of PNS integrin traffic have identified molecules that can be manipulated to increase axonal integrin expression, suggesting strategies for repairing the injured spinal cord.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Axones
/
Transducción de Señal
/
Integrinas
/
Regeneración Nerviosa
Límite:
Animals
Idioma:
En
Revista:
Curr Opin Neurobiol
Asunto de la revista:
BIOLOGIA
/
NEUROLOGIA
Año:
2014
Tipo del documento:
Article
País de afiliación:
Reino Unido