Incidence and treatment of lymphedema in heart transplant patients treated with everolimus.
Transplant Proc
; 46(7): 2334-8, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-25242782
ABSTRACT
BACKGROUND:
Proliferation signal inhibitors are increasingly used as immunosuppressive drugs in solid organ transplantation. Among their side effects peripheral lymphedema is rarely described in literature.METHODS:
All heart transplant patients treated with everolimus (de novo or maintenance) at our center (135 patients age 50.72±11.1 y, 115 male) were retrospectively analyzed. We considered the incidence of adverse events, particularly the appearance of peripheral edema (13 patients, 9.6%), and the correlation with preoperative characteristics, concomitant medications, other possible causes of edema, as well as all the measures developed for its therapeutic treatment. RESULTS ANDCONCLUSIONS:
Edema appearance, especially in lower limbs, was considered to be one of the most frequent side effects in heart transplant patients treated with everolimus. In some cases its regression was possible with an adjustment of drug dosages associated with diuretics and lymphatic drainage, but more often a suspension of the drug itself was required for complete regression of the symptoms.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Corazón
/
Sirolimus
/
Inmunosupresores
/
Linfedema
Tipo de estudio:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Transplant Proc
Año:
2014
Tipo del documento:
Article
País de afiliación:
Italia