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Systematic analysis of the intravoxel incoherent motion threshold separating perfusion and diffusion effects: Proposal of a standardized algorithm.
Wurnig, Moritz C; Donati, Olivio F; Ulbrich, Erika; Filli, Lukas; Kenkel, David; Thoeny, Harriet C; Boss, Andreas.
Afiliación
  • Wurnig MC; Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
  • Donati OF; Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
  • Ulbrich E; Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
  • Filli L; Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
  • Kenkel D; Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
  • Thoeny HC; Department of Diagnostic and Interventional Radiology, University Hospital Bern, Switzerland.
  • Boss A; Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Switzerland.
Magn Reson Med ; 74(5): 1414-22, 2015 Nov.
Article en En | MEDLINE | ID: mdl-25360990
PURPOSE: To systematically evaluate the dependence of intravoxel-incoherent-motion (IVIM) parameters on the b-value threshold separating the perfusion and diffusion compartment, and to implement and test an algorithm for the standardized computation of this threshold. METHODS: Diffusion weighted images of the upper abdomen were acquired at 3 Tesla in eleven healthy male volunteers with 10 different b-values and in two healthy male volunteers with 16 different b-values. Region-of-interest IVIM analysis was applied to the abdominal organs and skeletal muscle with a systematic increase of the b-value threshold for computing pseudodiffusion D*, perfusion fraction Fp, diffusion coefficient D, and the sum of squared residuals to the bi-exponential IVIM-fit. RESULTS: IVIM parameters strongly depended on the choice of the b-value threshold. The proposed algorithm successfully provided optimal b-value thresholds with the smallest residuals for all evaluated organs [s/mm2]: e.g., right liver lobe 20, spleen 20, right renal cortex 150, skeletal muscle 150. Mean D* [10(-3) mm(2)/s], Fp [%], and D [10(-3) mm(2)/s] values (±standard deviation) were: right liver lobe, 88.7 ± 42.5, 22.6 ± 7.4, 0.73 ± 0.12; right renal cortex: 11.5 ± 1.8, 18.3 ± 2.9, 1.68 ± 0.05; spleen: 41.9 ± 57.9, 8.2 ± 3.4, 0.69 ± 0.07; skeletal muscle: 21.7 ± 19.0; 7.4 ± 3.0; 1.36 ± 0.04. CONCLUSION: IVIM parameters strongly depend upon the choice of the b-value threshold used for computation. The proposed algorithm may be used as a robust approach for IVIM analysis without organ-specific adaptation.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Algoritmos / Procesamiento de Imagen Asistido por Computador / Imagen de Difusión por Resonancia Magnética Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2015 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Algoritmos / Procesamiento de Imagen Asistido por Computador / Imagen de Difusión por Resonancia Magnética Tipo de estudio: Prognostic_studies Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Magn Reson Med Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2015 Tipo del documento: Article País de afiliación: Suiza