Partial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortex.

Watanabe, Hirotaka; Iqbal, Minah; Zheng, Jin; Wines-Samuelson, Mary; Shen, Jie

Watanabe, Hirotaka; Iqbal, Minah; Zheng, Jin; Wines-Samuelson, Mary; Shen, Jie.

Afiliación

Watanabe H; Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, and.
Iqbal M; Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, and.
Zheng J; Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, and.
Wines-Samuelson M; Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, and.
Shen J; Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts 02115, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115 jshen@rics.bwh.harvard.edu.

J Neurosci ; 34(48): 15912-22, 2014 Nov 26.

Article en En | MEDLINE | ID: mdl-25429133

Asunto(s)

Envejecimiento/metabolismo; Corteza Cerebral/metabolismo; Neuronas/metabolismo; Presenilina-1/deficiencia; Presenilina-2/deficiencia; Envejecimiento/patología; Animales; Supervivencia Celular/fisiología; Corteza Cerebral/patología; Femenino; Masculino; Ratones; Ratones de la Cepa 129; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Transgénicos; Neuronas/patología

Palabras clave

Alzheimers disease; conditional knockout; dementia; gamma-secretase; neurodegeneration; neuronal survival

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Corteza Cerebral / Presenilina-1 / Presenilina-2 / Neuronas Límite: Animals Idioma: En Revista: J Neurosci Año: 2014 Tipo del documento: Article

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