DNA-protein crosslink repair: proteases as DNA repair enzymes.
Trends Biochem Sci
; 40(2): 67-71, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25496645
ABSTRACT
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions because they interfere with DNA transactions. The recent discovery of a yeast protease that processes DPCs proteolytically raises the question whether DPC proteases also exist in higher eukaryotes. We argue here that the yeast enzyme, Wss1 (weak suppressor of smt3), is a member of a protease family whose mammalian representative is Spartan (SprT-like domain-containing protein)/DVC1 (DNA damage protein targeting VCP). DPC proteases may thus be common to all eukaryotes where they function as novel guardians of the genome.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Recombinación Genética
/
Proteínas de Saccharomyces cerevisiae
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Enzimas Reparadoras del ADN
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Proteínas de Unión al ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania