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Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Franco, Francisco M; Jones, Darin E; Harris, Peter K W; Han, Zhenfu; Wildman, Scott A; Jarvis, Cassie M; Janetka, James W.
Afiliación
  • Franco FM; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA.
  • Jones DE; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA.
  • Harris PK; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA.
  • Han Z; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA.
  • Wildman SA; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA.
  • Jarvis CM; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA.
  • Janetka JW; Washington University School of Medicine, Department of Biochemistry and Molecular Biophysics and Alvin J. Siteman Cancer Center, 660 South Euclid Ave., St. Louis, MO, USA. Electronic address: janetkaj@wustl.edu.
Bioorg Med Chem ; 23(10): 2328-43, 2015 May 15.
Article en En | MEDLINE | ID: mdl-25882520
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Benzamidinas / Serina Endopeptidasas / Proteínas de Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Benzamidinas / Serina Endopeptidasas / Proteínas de Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos