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Retinal nerve fiber layer and macular thinning in systemic lupus erythematosus: an optical coherence tomography study comparing SLE and neuropsychiatric SLE.
Liu, G Y; Utset, T O; Bernard, J T.
Afiliación
  • Liu GY; University of Chicago, Chicago, USA gyliu@uchicago.edu.
  • Utset TO; Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, USA.
  • Bernard JT; Department of Neurology, University of Chicago, Chicago, USA.
Lupus ; 24(11): 1169-76, 2015 Oct.
Article en En | MEDLINE | ID: mdl-25888613
ABSTRACT

OBJECTIVE:

Due to the lack of reliable biomarkers in diagnosing and monitoring neuropsychiatric systemic lupus erythematosus (NPSLE), the aim of this study was to examine the utility of measurements obtained through spectral domain optical coherence tomography (SD-OCT) as a biomarker for NP involvement in SLE.

METHODS:

Retinal nerve fiber layer (RNFL) and macula scans were performed using SD-OCT on 15 NPSLE patients, 16 SLE patients without NP symptoms (non-NP SLE), and 16 healthy controls. Macular volume and thickness of the central macula and peripapillary RNFL were compared between the groups and to scores on two validated cognitive tests.

RESULTS:

NPSLE patients did not differ significantly from non-NP SLE patients in retinal thickness or macular volume. However, SLE patients as a whole showed significant RNFL and macular thinning compared to controls. Scores on the Trail Making Test B, a test of complex attention, showed significant correlation to temporal superior and temporal inferior RNFL thickness.

CONCLUSION:

Our results demonstrate RNFL thinning in SLE, and confirm the previous finding of high incidence of abnormal brain scans in SLE. These findings suggest that OCT measurements may be indicative of neurodegeneration in SLE and may be a useful biomarker for early cognitive impairment in SLE.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vasculitis por Lupus del Sistema Nervioso Central / Lupus Eritematoso Sistémico / Mácula Lútea / Fibras Nerviosas Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lupus Asunto de la revista: REUMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Vasculitis por Lupus del Sistema Nervioso Central / Lupus Eritematoso Sistémico / Mácula Lútea / Fibras Nerviosas Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lupus Asunto de la revista: REUMATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos