Antagonists of Metabotropic Glutamate Receptors Prevent the Development of Audiogenic Seizures.
Bull Exp Biol Med
; 159(1): 1-3, 2015 May.
Article
en En
| MEDLINE
| ID: mdl-26033576
ABSTRACT
Pretreatment with mGluR1 antagonist AIDA (1 mg/kg) nearly completely prevented the onset of tonic-clonic seizures and increased generation of NO in the cerebral cortex of rats with genetically determined audiogenic reaction to acoustic stimulation. Administration of mGluR5 antagonist MPEP (10 mg/kg) before audiogenic exposure was followed by a significant decrease in the degree of seizure and partially prevented increased generation of NO due to acoustic stimulation. These data indicate that mGlu receptors and NO play an important role in the pathogenetic mechanisms of audiogenic seizures.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Piridinas
/
Estimulación Acústica
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Epilepsia Tónico-Clónica
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Receptores de Glutamato Metabotrópico
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Antagonistas de Aminoácidos Excitadores
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Epilepsia Refleja
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Receptor del Glutamato Metabotropico 5
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Indanos
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Proteínas del Tejido Nervioso
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Óxido Nítrico
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2015
Tipo del documento:
Article