Double-blind randomised controlled trial of vitamin D3 supplementation for the prevention of acute respiratory infection in older adults and their carers (ViDiFlu).
Thorax
; 70(10): 953-60, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26063508
ABSTRACT
RATIONALE Low-dose vitamin D supplementation is already recommended in older adults for prevention of fractures and falls, but clinical trials investigating whether higher doses could provide additional protection against acute respiratory infection (ARI) are lacking. OBJECTIVE:
To conduct a clinical trial of high-dose versus low-dose vitamin D3 supplementation for ARI prevention in residents of sheltered-accommodation housing blocks ('schemes') and their carers in London, UK. MEASUREMENTS ANDMETHODS:
Fifty-four schemes (137 individual participants) were allocated to the active intervention (vitamin D3 2.4â mg once every 2â months +10â µg daily for residents, 3â mg once every 2â months for carers), and 54 schemes with 103 participants were allocated to control (placebo once every 2â months +vitamin D3 10â µg daily for residents, placebo once every 2â months for carers) for 1â year. Primary outcome was time to first ARI; secondary outcomes included time to first upper/lower respiratory infection (URI/LRI, analysed separately), and symptom duration. MAINRESULTS:
Inadequate vitamin D status was common at baseline 220/240 (92%) participants had serum 25(OH)D concentration <75â nmol/L. The active intervention did not influence time to first ARI (adjusted HR (aHR) 1.18, 95% CI 0.80 to 1.74, p=0.42). When URI and LRI were analysed separately, allocation to the active intervention was associated with increased risk of URI (aHR 1.48, 95% CI 1.02 to 2.16, p=0.039) and increased duration of URI symptoms (median 7.0 vs 5.0â days for active vs control, adjusted ratio of geometric means 1.34, 95% CI 1.09 to 1.65, p=0.005), but not with altered risk or duration of LRI.CONCLUSIONS:
Addition of intermittent bolus-dose vitamin D3 supplementation to a daily low-dose regimen did not influence risk of ARI in older adults and their carers, but was associated with increased risk and duration of URI. TRIAL REGISTRATION NUMBER clinicaltrials.gov NCT01069874.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
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Vitaminas
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Colecalciferol
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Suplementos Dietéticos
Tipo de estudio:
Clinical_trials
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Thorax
Año:
2015
Tipo del documento:
Article
País de afiliación:
Reino Unido