Linking Micronuclei to Chromosome Fragmentation.
Cell
; 161(7): 1502-4, 2015 Jun 18.
Article
en En
| MEDLINE
| ID: mdl-26091034
ABSTRACT
Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Daño del ADN
/
Rotura Cromosómica
/
Micronúcleos con Defecto Cromosómico
Límite:
Humans
Idioma:
En
Revista:
Cell
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos