Structure of shikimate kinase, an in vivo essential metabolic enzyme in the nosocomial pathogen Acinetobacter baumannii, in complex with shikimate.

Sutton, Kristin A; Breen, Jennifer; MacDonald, Ulrike; Beanan, Janet M; Olson, Ruth; Russo, Thomas A; Schultz, L Wayne; Umland, Timothy C

Sutton, Kristin A; Breen, Jennifer; MacDonald, Ulrike; Beanan, Janet M; Olson, Ruth; Russo, Thomas A; Schultz, L Wayne; Umland, Timothy C.

Afiliación

Sutton KA; Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203, USA.
Breen J; Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203, USA.
MacDonald U; Department of Medicine and The Witebsky Center for Microbial Pathogenesis, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Beanan JM; Department of Medicine and The Witebsky Center for Microbial Pathogenesis, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Olson R; Department of Medicine and The Witebsky Center for Microbial Pathogenesis, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Russo TA; Department of Medicine and The Witebsky Center for Microbial Pathogenesis, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Schultz LW; Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203, USA.
Umland TC; Hauptman-Woodward Medical Research Institute, Buffalo, NY 14203, USA.

Acta Crystallogr D Biol Crystallogr ; 71(Pt 8): 1736-44, 2015 Aug.

Article en En | MEDLINE | ID: mdl-26249354

Asunto(s)

Infecciones por Acinetobacter/microbiología; Acinetobacter baumannii/química; Acinetobacter baumannii/enzimología; Fosfotransferasas (Aceptor de Grupo Alcohol)/química; Fosfotransferasas (Aceptor de Grupo Alcohol)/metabolismo; Ácido Shikímico/metabolismo; Infecciones por Acinetobacter/metabolismo; Acinetobacter baumannii/crecimiento & desarrollo; Acinetobacter baumannii/metabolismo; Animales; Cristalografía por Rayos X; Humanos; Modelos Moleculares; Conformación Proteica; Ratas; Transducción de Señal

Palabras clave

Acinetobacter baumannii; antibiotic target; enzyme kinetics; essential gene; ligand-induced conformational change; multi-drug and extreme drug resistance; shikimate kinase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ácido Shikímico / Infecciones por Acinetobacter / Fosfotransferasas (Aceptor de Grupo Alcohol) / Acinetobacter baumannii Límite: Animals / Humans Idioma: En Revista: Acta Crystallogr D Biol Crystallogr Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos

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