Your browser doesn't support javascript.
loading
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.
Huang, Xi; He, Ye; Dubuc, Adrian M; Hashizume, Rintaro; Zhang, Wei; Reimand, Jüri; Yang, Huanghe; Wang, Tongfei A; Stehbens, Samantha J; Younger, Susan; Barshow, Suzanne; Zhu, Sijun; Cooper, Michael K; Peacock, John; Ramaswamy, Vijay; Garzia, Livia; Wu, Xiaochong; Remke, Marc; Forester, Craig M; Kim, Charles C; Weiss, William A; James, C David; Shuman, Marc A; Bader, Gary D; Mueller, Sabine; Taylor, Michael D; Jan, Yuh Nung; Jan, Lily Yeh.
Afiliación
  • Huang X; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • He Y; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Dubuc AM; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Hashizume R; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Zhang W; Developmental and Stem Cell Program, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Reimand J; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • Yang H; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Wang TA; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Stehbens SJ; The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  • Younger S; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Barshow S; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Zhu S; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Cooper MK; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Peacock J; Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, California, USA.
  • Ramaswamy V; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Garzia L; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Wu X; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Remke M; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Forester CM; Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
  • Kim CC; Howard Hughes Medical Institute, Department of Biophysics and Biochemistry, University of California, San Francisco, San Francisco, California, USA.
  • Weiss WA; Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • James CD; Developmental and Stem Cell Program, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Shuman MA; Developmental and Stem Cell Program, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Bader GD; Developmental and Stem Cell Program, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Mueller S; Developmental and Stem Cell Program, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Taylor MD; Developmental and Stem Cell Program, Arthur and Sonia Labatt Brain Tumor Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Jan YN; Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
  • Jan LY; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Nat Neurosci ; 18(9): 1236-46, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26258683
ABSTRACT
Over 20% of the drugs for treating human diseases target ion channels, but no cancer drug approved by the US Food and Drug Administration (FDA) is intended to target an ion channel. We found that the EAG2 (Ether-a-go-go 2) potassium channel has an evolutionarily conserved function for promoting brain tumor growth and metastasis, delineate downstream pathways, and uncover a mechanism for different potassium channels to functionally cooperate and regulate mitotic cell volume and tumor progression. EAG2 potassium channel was enriched at the trailing edge of migrating medulloblastoma (MB) cells to regulate local cell volume dynamics, thereby facilitating cell motility. We identified the FDA-approved antipsychotic drug thioridazine as an EAG2 channel blocker that reduces xenografted MB growth and metastasis, and present a case report of repurposing thioridazine for treating a human patient. Our findings illustrate the potential of targeting ion channels in cancer treatment.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tioridazina / Neoplasias Encefálicas / Sistemas de Liberación de Medicamentos / Evolución Molecular / Canales de Potasio Éter-A-Go-Go Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tioridazina / Neoplasias Encefálicas / Sistemas de Liberación de Medicamentos / Evolución Molecular / Canales de Potasio Éter-A-Go-Go Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos