Membrane microparticles: shedding new light into cancer cell communication.
J Cancer Res Clin Oncol
; 142(7): 1395-406, 2016 Jul.
Article
en En
| MEDLINE
| ID: mdl-26285684
ABSTRACT
BACKGROUND:
Microparticles (MPs) or ectosomes are small enclosed fragments (from 0.2 to 2 µm in diameter) released from the cellular plasma membrane. Several oncogenic molecules have been identified inside MPs, including soluble proteins XIAP, survivin, metalloproteinases, CX3CL1, PYK2 and other microRNA-related proteins; membrane proteins EGFR, HER-2, integrins and efflux pumps; and messenger RNAs and microRNAs miR-21, miR-27a, let-7, miR-451, among others. Studies have shown that MPs transfer their cargo to neoplastic or non-malignant cells and thus contribute to activation of oncogenic pathways, resulting in cell survival, drug resistance and cancer dissemination. DISCUSSION ANDCONCLUSION:
This review summarizes recent findings on MP biogenesis and the role of the MPs cargo in cancer and discusses some of the RNAs and proteins involved. In addition, the discussion covers evidence of (1) how and which signaling pathways can be activated by MPs in recipient cells; (2) recipient cell-type selectivity in incorporation of proteins and RNAs transported by MPs; and (3) how upon stimulation, stromal cells release MPs, promoting resistance to chemotherapeutics and invasiveness in cancer cells.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Comunicación Celular
/
Micropartículas Derivadas de Células
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Año:
2016
Tipo del documento:
Article
País de afiliación:
Brasil